Why is that microdeletions and microinsertions difficult to diagnosis using karotypes

Answer
             Karyotype is related to determine the size, shape and number of chromosomes in a single species of an organism.
Micro deletion is related to the deletion of any part of DNA in an organism, whereas microinsertion is the addition of extra DNA part in a particuar chromosomes.
In order to diagnose such abnormalities molecular level diagnosis should be studied using fluorescence in situ hybridization, irrespective of high-resolution chromosome results (Karyotyping).

The soviet union beat the us to the first successful launch, with the october 4, 1957, orbiting of sputnik 1, and later beat the us to have the first human in earth orbit, yuri gagarin, on april 12, 1961. the "race" peaked with the july 20, 1969, us landing of the first humans on the moon with apollo 11