Rheumatoid arthritis is a potentially debilitating disease that

rheumatoid arthritis (ra) is a chronic, inflammatory synovitis-based systemic disease of unknown etiology. it is characterized by multiple joints of the hand and foot joints, symmetry, invasive joint inflammation, often accompanied by extra-articular involvement and serum rheumatoid factor positive, which can lead to joint deformity and loss of function.

matrix metalloproteinase-3 (mmp-3) also known as stromelysin-1 and transin (ec 3.4.24.17) cleaves a number of substrates including cartilage proteoglycan, collagen types ii, iii, iv, v and ix, fibronectin, laminin, and can activate mmp 1. mmp-3 is secreted as 57 and 59 kda proenzymes and can be activated in vitro by organomercurials (e.g., 4 aminophenylmercuric acetate, apma) and in vivo by proteases via intermediate forms to a 45 kda active mmp 3 enzyme. further autolysis to a 28 kda form can also occur. mmp-3 is thought to play an important role in pathophysiological degradation processes associated with conditions such as rheumatoid arthritis and cancer cell invasion.

reference:

the answer is d. exposing corruption in the church

earthquakes in florida are rare because the state is not located near any tectonic plates. in fact, florida is tied for first place as having the fewest earthquakes of any state. much of florida is limestone and seafloor materials that is not conducive to earthquakes.

explanation: