The interaction between information systems and organizations is:
1. primarily guided by the decision making of middle- and senior-managers.
2. a complex, two-way relationship mediated by factors such as the environment and organizational structure.
3. is driven by the microeconomic forces of capital and labor.
4. successfully managed when the organization's existing culture and goals are seen as the driving force.

The correct answer is 2

Explanation:

Information system is the system which aims to support the operations, decision making and management of the organization. The system of organization is created or established in order to process, store, collect as well as distribute the information.

Organizations are those who uses the information system.

So, the interaction among the organizations and information system is the complex procedure, involve two way relationship which is mediated through factors like the structure of organization and environment.