After several days of starvation, the ability of the liver to metabolize acetyl-coa via the citric acid cycle is severely compromised. which combination of statements best explains this observation? when glycogen is depleted, gluconeogenesis is activated. gluconeogenesis uses intermediates from the citric acid cycle in order to prevent glycogen breakdown, amino acids are catabolized in the absence of dietary glucose, glycogen is broken down in the absence of dietary glucose, glycolysis is inhibited. amino acid catabolism uses intermediates from the citric acid cycle. after several days of starvation, glycogen levels will be depleted. pyruvate is in too low of abundance. the lack of citric acid cycle intermediates has no impact on the oxidation of acetyl-coa. after several days of starvation, glycogen levels will remain constant. under starvation conditions, transcription of citric acid cycle enzymes decreases the lack of citric acid cycle intermediates limits the oxidation of acetyl-coa.