When leonor michaelis and maude menten first derived the michaelis-menten equation they made some assumptions. select each statement that describes an assumption of the michaelis-menten model. 1) the vmax can be calculated by multiplying the km by 2 2) the formation of es from e+p is so small that this rate can be ignored. 3) the rate of formation of es is equal to the rate of loss of es 4) the enzyme can reach maximal velocity when saturated with substrate