Sulfur oxides carbon monoxides chlorofluorocarbons (cfcs)nitrates are responsible for the hole in the ozone layer.

The best answer for the question above would be the chloroflourocarbons or the CFCs. These chloroflourocarbons or CFCs are the ones responsible for the depletion of the ozone - which leads to leaving a hole in its layer. These gases eat out the ozone layer and allows harmful UV rays of the sun to come in the Earth.