Which of the following criteria are used to determine if a substance is a neurotransmitter? i. the chemical must be synthesized in the neuron. ii. when the neuron is active, the chemical is released and produces a response. iii. injection of the chemical mimics the effects of neuronal stimulation. iv. mechanisms exist for the removal of the chemical.

Explanation:

All of them. Dopamine is a neurotransmitter.

1. Dopamine is synthesized in the neuron by hydroxylating L-tyrosine via Tyrosine Kinase pathway.

2. Dopamine activates neuronal brain function.

3. Injection of L-DOPA mimics the dopamine and effects the same as neuronal stimulation.

4. Dopamine is converted to Adrenaline/Noradrenaline by Kinases and further removed from Kidneys by glucronidation.

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