Gwhich molecules directly participate in fatty acid synthesis by acting as energy sources? gtp citrate atp nadh nadph acetyl‑coa ethanol consumption inhibits gluconeogenesis by causing an increase in the concentration of nadh. nadh is a substrate for malate dehydrogenase, the enzyme that produces malate. an accumulation of malate favors the activity of malic enzyme. thus, an increase in nadh concentration increases the enzymatic activity of malic enzyme. the increase in nadh after ethanol consumption favors in the nadph concentration and fatty acid synthesis. therefore, ethanol consumption in an otherwise fasting state the risk of hypoglycemia.