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In untreated type 1 diabetes, the hepatocyte's citric acid cycle becomes overwhelmed with acetyl‑CoA from excessive fatty acid oxidation. Although the excess acetyl‑CoA is not toxic, it must be diverted into the formation of ketone bodies: acetone, acetoacetate, and D‑β‑hydroxybutyrate.
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In untreated type 1 diabetes, the hepatocyte's citric acid cycle becomes overwhelmed with acetyl‑CoA...
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