(20 Pt. s) Guys! You have to explain:
How weak base drugs behave in high acidic environment of stomach,?
Do they get protonated or donates protons?
Does it pass into blood stream via stomach?
Where would they get a chance to pass through the membranes and why?

Weakly basic drugs behaves different from acidic drugs which is discussed below.

Weakly basic drugs are those drugs which have an amine group associated with them. They are able to gain a proton to be come positively charged.

So drugs like quinine, ephedrine and aminopyrine which are basic got completely ionised in stomach.

The stomach can absorb those compounds which are lipid soluble. The acidic drugs like alcohols, Salicylic acid, aspirin, thiopental, secobarbital and antipyrine etc which are acidic gets absorbed by means of diffusion through the membrane.

But the basic drugs have charges on them which makes them lipophobic. So they cannot get absorbed through stomach. However weakly basic drugs sometimes get absorbed depending on their ionisation extent.

The rest goes to small intestine which has basic environment and there they gets absorbed via diffusion or facilitated diffusion.