Carboxylic acid can react with an inorganic chloride to make an acid anhydride or acid chloride. Does it matter which chloride we react the carboxylic acid with or do we just pick one to use

Check Explanation.

Explanation:

Carboxylic acids undergo nucleophilic substitution reactions where the nucleophile (-OH) is substituted by another nucleophile.

In cases such as the reaction with inorganic chlorides, which are strong electrophiles, the partially negatively charged carbonyl oxygen (δ-) can act as a nucleophile and attack the electrophile.

So, the inorganic chlorides that Carboxylic acids react with are the ones with electrophilic centres. The ones with centres that have space to expand and accept electrons new pair of electrons.

Such inorganic chloride include SOCl₂, PCl₃ and PCl₅.

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