Identify all statements that accurately describe the structure of the pyruvate dehydrogenase ( PDH ) complex.

The core of the complex is made up of several copies of E 1 .
A regulatory kinase and phosphatase are part of the mammalian PDH complex.
E 2 contains three domains.
The complex contains multiple copies of each of three enzymes.
Several copies each of E 1 and E 3 surround E 2 .

The statements that correctly describes pyruvate dehydrogenase includes:

- Several copies each of E 1 and E 3 surround E 2.

-A regulatory kinase and phosphatase are part of the mammalian PDH complex.

-E 2 contains three domains.

Explanation:

Pyruvate dehydrogenase is a hydrolase key enzyme in glucose metabolism which converts pyruvate to acetyl- ChoA. It also forms a complex that catalyzes an irreversible reaction that is the entry point of pyruvate into the TCA cycle. Pyruvate dehydrogenase complex contains E1, E2 and E3 enzymes that transform pyruvate, NAD+, coenzyme A into acetyl-CoA, CO2, and NADH. Also, A regulatory kinase and phosphatase are part of the mammalian PDH complex and E 2 contains three domains.

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