Electrospray ionization and atmospheric pressure chemical ionization are two methods that are used to introduce the eluate from the liquid chromatography column into a mass spectrometer. Which ionization method typically requires analyte ions to be in solution prior to reaching the interface between the column in liquid chromatography and the mass spectrometer?

Electrospray ionization

Explanation:

Electrospray ionization Is a soft ionization technique used in producing ions from macromolecules, it is employed especially in spectrometry where high voltage is used to create an aerosol from a liquid.It can be employed in Knowing molecular weights of molecules and biological macromolecules such as Peptides and proteins. Therefore, electrospray ionization is the method typically requires analyte ions to be in solution prior to reaching the interface between the column in liquid chromatography and the mass spectrometer

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