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Chemistry, 05.05.2020 04:13 Lizzy527663

The chloromethylated polystyrene resin used for Merrifield solid-phase peptide synthesis is prepared by treatment of polystyrene with chloromethyl methyl ether and a Lewis acid catalyst. The reaction involves the following steps: Reaction of the ether with the Lewis acid to form cation 1; Electrophilic aromatic substitution to form resonance stabilized cation 2; Deprotonation yields aromatic ether 3; Protonation to form protonated ether 4; Displacement by chloride ion to form the final product. Write out the mechanism on a separate sheet of paper and then draw the structure of the resonance contributors of the resonance stabilized cation 2.

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