Many metabolites are maintained at steady state concentrations that are far from equilibrium. A comparison K'_eq and Q, the mass-action ratio, can determine whether a metabolic reaction is far from equilibrium.
Fructose 6 Phosphate + ATP Fructose 1,6 Biphosphate + ADP
Calculate K'_eq for this reaction at T= 25.0 degree C delta G degree ' = -14.2 kj/mol
Calculate the mass-action ratio. Q, from the approximate physiological concentrations for rat heart tissue shown at the right.
Select the true statements about the PFK-1 reaction
The PFK-1 reaction in heart tissue does not reach equilibrium. In heart tissue, the PFK-1 products are more abundant than reactants.
In heart tissue, the PFK-1 reaction will be driven toward product formation.
Under standard conditions, the PFK-1 reaction reaches equilibrium when the concentrations_of all products and reactants are equal.