Describe Muller's Ratchet.

Muller's ratchet is a paradigmatic model in population genetics which describes the fixation of a deleterious mutation in a population of finite size due to an unfortunate stochastic fluctuation.

Explanation:

he uptake of drugs from the intestine is often strongly influenced by diffusion. for example, consider a water-insoluble steroid for treating inflammation that is solubilized in aggregates of detergent molecules, called micelles. these micelles, aggregates of 80 soap molecules, have a molecular weight of 24,000, a diameter of 2.6 nm, and a charge of -27. the positively charge ions (counterions) in this system are na".