Explain why the ability of PLP to catalyze an amino acid transformation is greatly reduced if the OHOH substituent of pyridoxal phosphate is replaced by OCH3OCH3.

Following are the responses to the given question:

Explanation:

In the given question the OH could be generated as the H-bond with both the N (nitrogen), which is used to place its N as the partially positive value(+). It is used to simplifies the addition for either its  AA with the imine C. In the above H-bond, the w N is not required as the possibility to use the OCH3

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