Engineering, 26.09.2019 23:00 22savage2017
In the biopharmaceutical industry, chemical engineers are responsible for the purification of monoclonal antibodies (mabs), which are produced in bioreactors. the purification process for the mabs happens in stages. the mabs are at a concentration of 2.5 g/l in the bioreactor, and are then moved to the stage 1 purification step. 90% of the entering antibodies leave the stage 1 purification step, and move on to the stage 2 purification. only 75% of the antibodies entering stage 2 survive to the product stage. given the above information, answer the following. show how you arrived at all of your answers by writing and solving appropriate balances. a) is this a batch or continuous process? transient or steady state? b) draw and label a flowchart of this process. c) what does the volume of the bioreactor need to be to for a final mabs yield of 5 kilograms? d) given the volume you just calculated, what is the initial weight of the mabs in the bioreactor? e) if the concentration in stage 1 is 15 g/l and in stage 2 is 50 g/l, how do the volumes of stage 1 and stage 2 compare to each other, and to the original bioreactor? explain your reasoning.
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In the biopharmaceutical industry, chemical engineers are responsible for the purification of monocl...
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