G Double‑reciprocal, or Lineweaver–Burk, plots can reveal the type of enzyme inhibition exhibited by an inhibitor. Competitive inhibitors increase the K M without affecting the V max . Noncompetitive inhibitors decrease the V max without affecting the K M . Uncompetitive inhibitors decrease both the K M and V max . A Lineweaver Burk plot shows two lines representing the kinetics of an enzyme with and without inhibitor. The x-axis plots the inverse of the substrate concentration, and the y-axis plots the inverse of the reaction velocity. The x-intercept of the line with inhibitor is more negative than the line with no inhibitor. Both lines have the same y-intercept. Based on the Lineweaver–Burk plot, what type of enzyme inhibition is exhibited by the inhibitor?

competitive

noncompetitive

uncompetitive

cannot be determined

The answer is competitive inhibitor.

Explanation:

Line-Weaver Burk Plots are designed by Hans Lineweaver and Dean Burk in 1934 and they are used to show the inhibition process of the enzymes in biochemistry.

In the question we are given the description of competitive inhibitors, non-competitive inhibitors and uncompetitive inhibitors. According to the example given later where the x-axis plot and y-axis plot is described with their interceptions of the x and y axis, since both lines have the same y intercept and the no-inhibitor line is more negative than the inhibitor line, we can deduce that the type of enzyme inhibition is exhibited by a competitive inhibitor.

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