You try another drug candidate with the DNA target and find that this drug candidate has a large negative enthalpy change upon DNA binding, and the entropy change is small and positive. For each aspect of your observations, suggest an explanation (at the molecular level) and identify an appropriate experiment to test your hypothesis by classifying the following interpretations and experiments accordingly. Drag an appropriate conclusions and experimental tests to their respective bins. 1. acquire a crystal structure to further support the interpretation
2. indicates that spontaneity is almost exclusively driven by intermolecular interactions
3. indicates that there are no significant differences between the types of interactions between the various molecules and macromolecules
4. heat the solution and make another measurement
5. increase the ion concentration and compare the values to validate the interpretation
6. indicates that DNA-drug intermolecular interactions are favorable
A. Large negative enthalpy change
B. Small positive entropy change
C. Invalid conclusion and non-applicable experiment