Spain’s recommended route to north New Spain followed the original route of Andres do Campo, which follows the .
A.
Mississippi and Red Rivers
B.
present-day Interstate 35
C.
Arkansas River
D.
Brazos River

The Answer is A.

Spain's recommended route to north New Spain followed the original route of Andres do Campo, which follows the Mississippi and Red Rivers. New Spain was a part of the Spanish colonial empire, with its capital in Mexico City, previously called Tenochtitlan, capital of the Aztec Empire

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i don't know sorry i cannot read a novel in 30 min.

explanation:

but just in case i think the answer is b.