Which type of context clue in the sentence can help you understnd the meaning of despondent

The true confessions of charlotte doyle and "jonah and the whale" have which theme in common?

Excerpt from jane eyre charlotte bronte 2 i was glad of it: i never liked long walks, especially on chilly afternoons: dreadful to me was the coming home in the raw twilight, with nipped fingers and toes, and a heart saddened by the chidings of bessie, the nurse, and humbled by the consciousness of my physical inferiority to eliza, john, and georgiana reed.

What is a mechanism by which organisms maintain homeostasis when the level of one substance influences the level of another substance or the activity of an organ.