What major river flows through the south of the U. S.A?

Mississippi River

Explanation:

It goes north to south and its flows 2,340 miles north to south from Minnesota to the Gulf of Mexico in Louisiana

Mississippi River

The Mississippi River is one of the most important rivers in the United States. It flows 2,340 miles north to south from Minnesota to the Gulf of Mexico in Louisiana.

Explanation:

The Mississippi River is one of the most important rivers in the United States. It flows 2,340 miles north to south from Minnesota to the Gulf of Mexico in Louisiana.

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