Which two factors most likely contributed to the change in this lake

The most likely factors that contributed to the changes in Lake Urmia are the population increase and increased water demand.

Explanation:

A is not correct because this lake, as all lakes, is not connected to the sea, so the sea levels can not influence its water levels.

B is not correct because if it was a case of regular floodings the lake would have gained more water, not lose it.

C is correct because the rapid rise of the population in Iran has led to much bigger usage of natural resources, including water resources.

D is not correct because the increased fish harvesting has no effect on the water depth or water volume of the lake.

E is correct because the increased water demand for different purposes is often the prime factor that leads to overexploitation of the water resources and often causing huge damage to them.