A. Christopher Columbus enslaves native peoples in the Americas. B. Portugal conquers indigenous peoples in the Caribbean.
C. The Muisca religion becomes popular in South America.
O D. The Maya civilization spreads across Central America.
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Correct answer is C. The Muisca religion becomes popular in South America.

Explanation:

A is not correct answer as Columbus was the first to come to this region, which means that it couldn't happen before arrival of Europeans in Caribbean.

B is also not correct as Portugal came to this region after Columbus discovered America.

C is correct as Muisca religion is closely tied with Chibcha civilization. Actually Muisca people are even often called Chibcha. This religion mostly spread on the soil of todays Colombia.

D is not correct as Maya civilization reached its peak much earlier in their classical period which lasted until 9th Century.

ń, wǒ shuō yīngyǔ, dàn wǒ huì shuō qítā yǔyán, rú xībānyá yǔ fǎyǔ yìdàlì yǔ hé pǔtōnghuà, suǒyǐ bùyào pànduàn, dànshì