What is the difference between secondary prevention and tertiary disease prevention? secondary prevention strategies focus on preventing the disease from occurring while tertiary prevention strategies focus on detecting a cure for the disease. secondary prevention strategies focus on detecting diseases in the earliest stages while tertiary prevention strategies focus on limiting the disease's progression. tertiary prevention strategies focus on preventing the disease from occurring while secondary prevention strategies focus on detecting a cure for the disease. tertiary prevention strategies focus on detecting diseases in the earliest stages while secondary prevention strategies focus on limiting the disease's progression.