Are manufactured by the brain to relieve pain.

Endorphins

Explanation:

Endorphins act as analgesics, which means they diminish the perception of pain. They also act as sedatives. They are manufactured in your brain, spinal cord, and many other parts of your body and are released in response to brain chemicals called neurotransmitters.

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i think your answer is c. measurement system in which the medication dosage was calculated.