Which of the following statements is true regarding protein structure determination?
a. mass spectrometry is the fastest way to determine the three-dimensional structure of a polypeptide or protein, regardless of its size.
b. a protein’s three-dimensional structure can be reliably predicted from its amino acid sequence by computer algorithms that access the vast quantities of structural information archived in public databases.
c. mass spectrometry can be used to determine the amino acid sequences of a complex mixture of different proteins.
d. determination of a protein’s structure by x-ray crystallography does not require prior knowledge of its amino acid sequence.
e. nuclear magnetic resonance can be used to determine the structure of proteins that are too large to crystallize.