Well-conducted randomized clinical trials and over a decade of use in clinical practice indicate that a large proportion of breast cancer can be cured among women with early breast cancer if the treatment is used on women with early breast cancer.
a= grade a
b= grade b
c= grade c
d= grade d
e= grade i

The correct answer is A.

Explanation:

Grade A of recommendation is defined when there is good, strong evidence that the practice involved has a benefit on the patients.

To stablish that there is good, strong evidence, a well conducted clinical trial is necessary. This means that the clinical trial should be randomized and the sample under study must be representative of the population of patients.  

The grade A of recommendation encourage physicians to offer or provide the service/treatment to their patients if they match the criteria.