The duct that connects the pancreas to the duodenum can sometimes become blocked. what is the result? nothing happens because the pancreas does not produce digestive enzymes. the digestive enzymes produced by the pancreas still enter the duodenum because they travel by the blood to reach the duodenum, not by a duct. the digestive enzymes produced by the pancreas enter the large intestine instead and digestion proceeds as normal. the digestive enzymes are not affected because they are stored in the gallbladder until they are needed in the duodenum. the digestive enzymes back up into the pancreas and may start to digest the pancreas.