The nurse is teaching the client about his prescribed prednisone. which statement, if made by the client, indicates that further teaching is necessary?

Answer and Explanation:

   Prednisone is a synthetic corticosteroid anti-inflammatory, antirheumatic and antiallergic medicine that is indicated for the treatment of various endocrine, musculoskeletal, rheumatic, collagen, dermatological, allergic, ophthalmic, respiratory, haematological, neoplastic and other diseases that respond to treatment with corticosteroids. Usually is administered orally but can also be administered by intramuscular injection and can be used for a large number of different diseases. Prednisone is a pro-drug, which means that is converted by the liver to prednisolone, which is the active metabolite and also a steroid.

 Mechanism of action: The receptor-glucocorticoid complex goes to the cell nucleus and causes some DNA changes that stimulate or suppress certain protein synthesis of the organs. This changes the immune response and the production of some inflammation mediators. The drug binds to the nuclear receptor in the cell, stimulates the inactive RNA polymerase. This RNA produces a protein called Lipocortin that inhibits phospholipase A2. Without phospholipase A2, there is no breakdown of membrane phospholipid containing arachidonic acid. Without this acid there is no later prostaglandin synthesis, responsible for inflammation symptoms .

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