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Isabela
In 1493, during his second voyage, Columbus founded Isabela, the first permanent Spanish settlement in the New World, on Hispaniola. After finding gold in recoverable quantities nearby, the Spanish quickly overran the island and spread to Puerto Rico in 1508, to Jamaica in 1509, and to Cuba in 1511.

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Depression is lifelong, though you can get medication to with it. the difference between sadness and depression is that sadness lasts a little bit, depression last a long time and it goes on and off. people usually get depression through experiences they have been through, or genetics.