what drug can be used to decrease the need for transfusion by increasing the number of red blood cells?

Erythropoiesis-stimulating agent (ESA)

Explanation:

The "ESA" minimizes the need for blood transfusions, especially when it comes to illnesses that needs such treatment. Once the ESA is administered through injection, the bone marrow in the body produces a specific amount of red blood cells (RBCs) needed to maintain a necessary hemoglobin level.

This drug is commonly given to patients with anemia. It can also be given to those undergoing chemotherapy, those who have kidney diseases and HIV.