How is the case of children with hormonal abnormalities an example of a natural experiment? Are there any limitations to its validity as a natural experiment?

Due to uncontrollable by the researcher.

Explanation:

The case of children with hormonal abnormalities an example of a natural experiment because these abnormalities can't be controlled by the researcher or investigator. All those things which can't be controlled by the humans or researcher is considered as natural experiment. The main limitation of this experiment is the hormonal abnormalities, if the researcher is able to control this hormonal abnormalities then the experiment is longer be considered as natural experiment.

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exposure to hazardous carcinogens and toxic substances can cause breathing problems, such as copd and various types of cancer. it also increases the risk of heart attacks and strokes and has serious (but no less unattractive) side effects, such as aging, yellow teeth, a terrible smell and damage to the vocal cords.