Which is the strongest indication that your friend is going through a depression? a. she rejects all social invitations. she used to be very social. b. she is angry with you. she was your good friend earlier. c. she goes out of town without telling you. she used to tell you everything.

The correct answer is A.

The strongest indication that your friend is going through a depression would be that she rejects all social invitations whereas before she used to be very social. A sign of depression is social isolation. People tend to isolate themselves away from others as they cannot cope with interacting.