What can be the cause of weakened muscle and kidney functioning?

Does the weight loss program have practical significance? a. no, the program is not practically significant because the results are likely to occur even if the weight loss program has no effect. b. yes, the program is practically significant because the results are too unlikely to occur by chance. c. yes, the program is practically significant because the amount of lost weight is large enough to be considered practically significant. d. no, the program is not practically significant because the amount of weight lost is trivial.