"down the ohio up the mississippi and westward on the missouri river" describes the principal route of which group

The correct answer to this open question is the following.

"Down Ohio up the Mississippi and westward on the Missouri River" describes the principal route of the Seneca and Shawnee.

The Shawnee Indian tribe lived in the area of the Ohio River, but when the Indian Removal Act was enacted in 1830, they had to relocate to the western territories of the Mississippi River, where they intermingle with the Seneca Native American Indian tribe. In December 1932, both tribes signed a cooperation agreement called "the United Nation of Seneca and Shawnee," and settled the Indian Territory of what today is Oklahoma.

i believe the answer is:

-   william jennings bryan is a democrat while mckinley was a republican

at that time, the segment of population that choose for democratic party were the voters with low economic background and vice versa

- william jennings has support of populists and wants to have inflation to farmers while mckinley has support of bankers and businessmen , doesn't want inflation

the fixed value of gold make the large business able to stack up their gold without   being worried that it would devaluated.

- william jennings supported the silver standard while mckinley supported the gold standard

according to jenning, using other metal beside gold could the poor people to have more purchasing power and them advance in the society.