How did columbian exchange affected some native peoples

The Columbian Exchange greatly affected almost every society on earth, bringing destructive diseases that depopulated many cultures, and also circulating a wide variety of new crops and livestock that, in the long term, increased rather than diminished the world human population.

the enslaved people onboard suffered from illness with some frequency

the doctrine of nullification recommended that states living inside the union have the one-sided, inalienable ideal to void any law made by the national government that could be esteemed illegal.

the united states was shaped based on a general agreement among its individual states. hence, it is inferred that under the hypothesis of invalidation, since the states are the establishment of the union, they have the ability to referee and disprove unlawful laws.