What kind of issue requires a 2/3 vote in the senate?

Override a Presidential Veto (2/3 majority in both the House and the Senate — Article 1, Section 7) Ratify a treaty (2/3 majority in the Senate — Article 2, Section 2) Passing of a Constitutional Amendment by Congress (2/3 majority in both the House and the Senate — Article 5)

Override a Presidential Veto and Passing of a Constitutional Amendment

hope this helps :)

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missouri compromise of 1820 which prohibited slavery