What was a problem for the federalists in 1788?

Many states were not ready to ratify the constitution, is the correct answer.

Explanation:

In the history of America, the period between 1788-1800 is known as the Federalist Era.  This was the time when the politics of the United States was dominated by the Federalist Party. The period witnessed the ratification of the original constitution of the United States. However, the main problem the Federalists face was that many of the states were not ready to ratify the constitution.

the answer is b: an economic crisis throughout the country.