Alcohol affect on the circulatory system can lead to

organs may have lack of nutrients and oxygen as heart isn't pumping blood as the alcohol can affect heart.

break in  stomach and aesophagus, which can lead to bleeding, eventually causing death

the answer to fill in the blank in this question would be the word resource, it is defined as the money, material or people (since human resource is a very valuable good) that a company or a person has at disposition (meaning they can use the resource as they see fit), to be able to complete a task or achieve a goal.