Which is one major problem that has resulted from globalization in the 20th and 21st centuries?

Diseases can spread around the world more quickly and economic instability

Explanation:

Globalization led to many problems during the past centuries; however, the major problem was the spread of different diseases that were spread soon due to change in climate. The actions of one country were also likely to cause problems in other countries, and this may spread across the entire world, requiring high collaboration among the countries affected. It was, therefore, necessary for the concerned authorities to set up and regulation that would prevent such challenges.

that was the type of government the spanish colonists were used to.