Describe the major difference between federalists and antifederalists.

federalists were in favor of increased taxes to support public programs, antifederalists were opposed to raising taxes.

federalists favored the constitution; antifederalist favored stronger state governments.

federalists wanted to create political parties for government: antifederalists were opposed to political parties.

federalists were british sympathizers; antifederalists were not.

The answer is:

Federalists favored the Constitution; Antifederalist favored stronger state governments.

Explanation:

The Anti-Federalists  didn't  want to have another government controlling power as Britain was. They wished the state to have government power. They believed that the Constitution created a Strong Central government who favored the wealthy business class which threatened the power of the state and the common man. The solution to this would be a Bill of Rights which the Federalists opposed as they believed it would not include each and every right causing those missing to be broken and abused.

i would go with the last one