Item 2 which resolution between the united states and spain solved the boundary disputes associated with the louisiana purchase? disputes continued between the two nations until mexico gained its independence from spain and borders were clearly defined. the two countries agreed on the location of borders to the east and west of louisiana in the adams-onis treaty. the two nations submitted their border disagreements to the world court for arbitration and settlement. as clashes between spain and the united states increased, france stepped in to clarify land included in the sale