Regions are always defined by

A region is an area of land that has common features. A region can be defined by natural or artificial features. Language, government, or religion can define a region, as can forests, wildlife, or climate. Regions large or small are the basic units of geography.

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C. Many different factors

Explanation:

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answer; /// i do believe that the correct answer is (a); a farming tribe that settled primarily along the mississippi and arkansas rivers;