Which of the following was not a major cause of a large scale loss of life in the late medieval Western Europe

If this is a true or false question i would say true

How  did spanish  power increaseunder charles  v and philip ii? in 1519,charles  v inherited a huge empire. he became king of  spain  and was also the heir to the hapsburg empire. during his 42-year reign, philip worked to expand  spanish  influence, strengthen the catholic church, and make his own power absolute. hope this !