Which best states how major works produced during the High Renaissance, such as Mona Lisa, affected European culture?

Major works produced during the High Renaissance emphasized beauty and led to a revival of classical influence.
Major works produced during the High Renaissance emphasized spirituality and led to a revival of church influence.
Major works produced during the High Renaissance emphasized naturalism and led to a revival of secular influence.
Major works produced during the High Renaissance emphasized science and led to a revival of scientific influence.