The Commerce clause of the Constitution says, “the Congress shall have the Power... to regulate Commerce...among the several states.” Does the clause apply if a state wants to make regulations so that its stores only sell milk from cows in that state?

Under the US Court of Appeals for the Eighth Circuit's interpretation, the Commerce Clause required that state laws regulating commercial activity that discriminates against out-of-state residents must serve some legitimate purpose that cannot be served in a nondiscriminatory way.

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