During the Lewis and Clark expedition,

The transcontinental railroad provided a means of fast transportation. it cut a 6 month trip into 6 days, created jobs for many people and encouraged immigration. the homestead act played a huge role in western expansion; it allowed settlers to begin a fresh start, and gave them land in exchange for their residence for up to five years and a small fee.

The constant presence of diseases or infectious agents within a given geographic area or population group. it may also refer to the usual prevalence of a given disease with such area or group. it includes holoendemic and hyperendemic diseases. a holoendemic disease is one for which a high prevalent level of infection begins early in life and affects most of the child population, leading to a state of equilibrium such that the adult population shows evidence of the disease much less commonly than do children (malaria in many communities is a holoendemic disease). a hyperendemic disease is one that is constantly present at a high incidence and/or prevalence rate and affects all groups equally. so probably family history.