How did traders get the spices and textiles from Asia back to Europe when the Silk Road stopped operating ?

The tobacco industry was developed by of north carolina.

Which of the following was a difficulty faced by the ottoman empire in the 1700s and 1800s?   a.  financial independence      b.  lack of trained artisans      c.  refusal to trade with other nations      d.  rebelling ethnic groups

How does a comet change when it comes close to the sun